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Technical Data |
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B0130-05 |
Basic Hair Keratin 1 (ghHb1, ghHKb1, Hair Keratin K2.9, HB1, Hb-1, hHAKB2-1, Keratin 81, Keratin-81, K81, KRT81, Keratin Type II Cuticular Hb1, KRTHB1, Metastatic Lymph Node 137 Gene Protein, MLN 137, MLN137, Type II Hair Keratin Hb1, Type-II Keratin Kb21 |
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Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq] Applications: Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1ug/ml-3ng/ml Western Blot: 1:500-1:1,000 Immunohistochemistry (paraffin): 1.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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