Technical Data
B0902E
BD3 full length, Mouse Control Peptide (beta-Defensin 3)
100ug
Molecular Biology Storage: -20°CShipping: Blue Ice
Control Peptide for (affinity purified) and (antiserum).
Synthetic peptide, 63 aa precursor (mature peptide 24-63 aa).

Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfides and a largely b-Sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms.

The genes encoding human and -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated – and -based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six –defensin (cryptidins), HD 1-6 (HD1-4 are also known as HNP1-4 for Human Neutrophil Peptides), and two -defensins, HBD-1 and HBD-2, have been identified to date. Rat (RBD-1 and RBD-2) and mouse (MBD1-4) homologues of the human beta-defensin have also been identified. a-defensins are encoded by genes designated DEFA1-6, whereas human b-defensins are encoded by the DEFB1 and DEFb2 genes

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Concentration: As reported
Form: Purified
Specificity: The MBD-3 sequence is ~ 50% conserved bovine and human beta defensin-3. Biological activity has not been established.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1.) Bals R et al (1999) Infect. Immun. 67, 3542-3547;
2.) Harder et al (1997) Nature 387, 861;
3.) Ganz T (1999) Science 286, 420;
4.) Yang D et al (1999) Science 286, 525.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.