Technical Data
BD4, Mouse Control Peptide (beta Defensin-4)
Molecular Biology Storage: -20CShipping: Blue Ice
MBD-4 is synthesized from 63 aa precursor. An 11 aa peptide from MBD-4 sequence near the N-terminus of mature defens.

Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfides and a largely b-Sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms. In leukocytes, these peptides are stored in cytoplasmic granules and are released into phagolysosomes where they contribute to the killing of engulfed microorganisms.

The genes encoding human a and -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated a-and -based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six a -defensin (cryptidins), HD 1-6 (HD1-4 are also known as HNP1-4 for Human Neutrophil Peptides), and two -defensins, HBD-1 and HBD-2, have been identified to date. Rat (RBD-1 and RBD-2) and mouse (MBD1-4) homologues of the human beta-defensin have also been identified.
Source: Mouse synthetic peptide
Purity: Highly purified
Concentration: As reported
Form: Supplied as a liquid in PBS, pH 7.2
Specificity: Specific mouse defensin-4. No significant homology exists with human beta-defensins-4 or other defensins. Available for antibody blocking to confirm specificity of antibodies

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
(1) Jia HP et al (1999) gene accession # AF155882; Harder et al (1997) Nature 387, 861; Ganz T (1999) Science 286, 420; Yang D et al (1999) Science 286, 525.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.