Technical Data
B0981-23J
Beclin-1, CT (Coiled-coil Myosin-like Bcl-2-Interacting Protein)
Description:
May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy. SUBUNIT: Interacts with GOPC and GRID2. Interacts with Bcl-2.

Cellular Localization:
Cytoplasm (Potential). Golgi apparatus; Golgi membrane; peripheral membrane protein. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Tissue Specificity:
Ubiquitous. Belongs to the beclin family.

Applications:
Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
A synthetic peptide corresponding to the C-terminal of human Beclin-1 conjugated to Blue Carrier Protein. The sequence is homologous with mouse and rat form of Beclin-1.
Purity:
Serum
Form
Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Specificity:
IHC and WB confirmed the specificity for Beclin-1. Species Crossreactivity: Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Liang,X.H., et al. J. Virol. 72 (11), 8586-8596 (1998) ; 2. Aita V.M., et al. Genomics 59:59-65(1999). ; 3. Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004) ; 4. Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) ; 5. Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) ; 6. Levine B. Cell. 120(2):159-62. (2005)