Technical Data
Berninamycin A (Berninamycin, Antibiotic U27810)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistence. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

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Source: Streptomyces sp.
Purity: >99%
Form: White solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Berninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al., J.Am.Chem.Soc. 1976, 98, 299. 2. Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303. 3. Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et. al. , Cancer Res. 2006, 19, 9731.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.