		Technical Data
B2553-08A	Bone Morphogenetic Protein 2, 283-396aa, Recombinant, Human (BMP2)	100ug

Growth Factors, Cytokines

Storage: -20°CShipping: Blue Ice

BMP-2 (Bone morphogenetic protein 2) is multi-functional growth factors that belong to the transforming growth factor beta (TGF beta) superfamily. It plays an important role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility. Recombinant human BMP-2 protein was expressed in E. coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.

Endotoxin Level:
1.0 EU per 1 ug of protein (determined by LAL method)15% SDS-PAGE (3ug)

Molecular Weight: 13kD (115aa)

AA Sequence:
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM
LYLDENEKVV LKNYQDMVVE GCGCR

Storage and Stability:
For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
13kD

Source: E. coli
Purity: 95% by SDS-PAGE
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in 10 mM Sodium Citrate, pH 3.5, 10% glycerol.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

1. Chen D., et al. (2004). Growth factors. 22(4):233-41 2. Schliephake H., et al. (2005). Clin Oral Implants Res. 17(6):666-72

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.