Technical Data
B2553-34B
Bone Morphogenetic Protein 7, 293-431 aa, Recombinant, Human (BMP7, OP-1, Osteogenic Protein-1)
100ug
Growth Factors, Cytokines Storage: -20°CShipping: Blue Ice
Bone morphogenic protein-7 (BMP-7/OP-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. Like other members of the BMPs family, it plays a role in calcium regulation and bone homeostasis. BMPs have been also shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP7 also has the potential for treatment of chronic kidney disease. Recombinant human BMP-7 protein, aa293-431, was expressed in E. coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.

AA Sequence:
MSTGSKQRSQ NRSKTPKNQE ALRMANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT
LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH LEHHHHHH

Storage and Stability:
For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
16.8kD
Source: E. coli
Purity: ~ 95% by SDS-PAGE. Endotoxin: 1EU/1ug of protein (LAL).
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in 10mM sodium citrate buffer, pH 3.5, 10% glycerol.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. González EA., et al. (2002) Kidney Int. 61(4): 1322-31 2. Tseng YH., et al. (2008) Nature. 454(7207): 1000-4

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.