Technical Data
B2570-28
Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989)
500ug
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Technical Data |
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B2570-28 |
Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989) |
500ug |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Borrelidin is an unusual nitrile containing metabolite isolated from Streptomyces. Originally discovered as active against against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery displaying activity against drug-resistant Plasmodia. Purity: >99% by HPLC Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO. CAS Number: 7184-60-3 Molecular Formula: C28H43NO6 Molecular Weight: 489.64 |
Source: Streptomyces sp Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. J. Biol. Chem. 2005, 280, 571. 2. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi T. et al. J. Antibiot. 1997, 50, 671. 3. Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura T. et al. J. Antibiot. 2003, 56, 709. 4. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. Otoguro K. et al. J. Antibiot. 2003, 56, 727.
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