Technical Data
Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989)
Biochemicals Storage: -20CShipping: Blue Ice
Borrelidin is an unusual nitrile containing metabolite isolated from Streptomyces. Originally discovered as active against against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery displaying activity against drug-resistant Plasmodia.

Purity: >99% by HPLC

Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO.

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Streptomyces sp

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among
threonyl-tRNA synthetases. Ruan T. et al. J. Biol. Chem. 2005, 280, 571.
2. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix
culture model. Wakabayashi T. et al. J. Antibiot. 1997, 50, 671.
3. Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA
synthetase and caspases are independently involved in suppression of proliferation and induction of
apoptosis in endothelial cells. Kawamura T. et al. J. Antibiot. 2003, 56, 709.
4. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic,
borrelidin, against drug-resistant strains of Plasmodia. Otoguro K. et al. J. Antibiot. 2003, 56, 727.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.