Technical Data
C0002-03A
C-1 Inhibitor (C1-INH)
Description:
C1 Inhibitor is a plasma protein that plays a pivotal role in the regulation of the early stages of the classical complement pathway and the contact activation pathways. It is a protease inhibitor acting as a competitive substrate for its target enzymes. These cleave a 34 aa peptide, the remainder of the C1 Inhibitor molecule binding to the protease causing irreversible inhibition. C1 inactivator is one of only two known enzymic inhibitors of C1s, the other, nexin I, is far less effective. The mean serum concentration of C1 Inhibitor is 0.2g/L. C1 iInhibitorr consists of a single heavily glocosylated polypeptide chain with a molecule weight of 104kD.

Applications:
Suitable for use in ELISA. Other applications not tested

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabHighly Purified
SizeStorageShippingSourceHost
10ml-20CBlue IceHumanGoat
Concentration:
As reported
Immunogen:
Purified human C-1 esterase inhibitor.
Purity:
Purified by defibrination, delipidation and solid phase chromatography.
Form
Supplied as a liquid in 0.05M tris, pH 7.5, 0.5M sodium chloride, 0.1% sodium azide.
Specificity:
Recognizes C-1 Inhibitor (esterase inhibitor). Monospecific by IEP with neat antibody versus 2x pooled human serum and neat pooled human plasma.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.