Technical Data
C0010-02J
Complement C1q (Complement Component 1, q Subcomponent)
Description:
Human complement component 1, q subcomponent (C1q) is a 156kD secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

Applications:
Suitable for use in Immunodiffusion. Other applications not tested.

Recommended Dilution:
Immunodiffusion: Neat
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabHighly Purified
SizeStorageShippingSourceHost
1ml-20CBlue IceHumanSheep
Concentration:
Not determined.
Immunogen:
Human C1q, purified from plasma.
Purity:
Purified by Ion Exchange chromatography.
Form
Supplied as a liquid in glycine buffered saline, pH 7.4, 0.09% sodium, 0.1% azide, 0.01% EACA, 1mM Benzamidine EDTA.
Specificity:
Recognizes human C1q.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.