Technical Data
C0104-70Q
CACNA2D2 (KIAA0558, Voltage-dependent Calcium Channel Subunit alpha-2/delta-2, Voltage-gated Calcium Channel Subunit alpha-2/delta-2)
Description:
Cacna2d2 is an alpha subunit 2/delta regulatory subunit of the voltage-gated calcium channel. The human Cacna2d2 corresponds to the mouse mutant ducky phenotype, which is a model for absence epilepsy, characterized by seizures and ataxia. CACNA2D2 overexpression has been implicated in the apoptosis of NSCLC cells by changing the intracellular calcium concentration and disrupting the mitochondrial membrane.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a,k3A4Affinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanMouse
Concentration:
~0.1mg/ml
Immunogen:
Recombinant corresponding to aa65-163 from human CACNA2D2 with GST tag. MW of the GST tag alone is 26kD.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
Recognizes human CACNA2D2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.