Technical Data
C0105-01
CAD (Caspase Activated Deoxyribonuclease)
Description:
Applications:
Western Blotting: 1:500-1:1000
Optimal working dilutions to be determined by researcher.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to amino acids 205-222 of mouse CAD.
Purity:
Purified IgG prepared by affinity chromatography.
Form
Supplied as a liquid in PBS with 0.02% sodium azide.
Specificity:
CAD (Caspase Activated Deoxyribonuclease) is the mouse homologue of human DFF-40.CAD is released and activated by caspase cleavage of ICAD and eventually causes degradation of nuclear DNA. Recognizes the 40kD CAD in Western blots.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Enari, M. et al. (1998). A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50.2. Sakahira, H. et al. (1998). Cleavage of CAD inhibitor in CAD activation and DNA degradati