		Technical Data
C0107-05C	Cadherin 6, NT (K-Cadherin, Kidney Cadherin, CDH6, Cadherin-6)

Description:
CDH6 is a type II classical cadherin from the cadherin superfamily. It is a calcium dependent cell-cell adhesion membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of the CDH6 gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

Applications:
Suitable for use in ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:50-1:100
ELISA: 1:1,000
Immunohistochemistry: 1:10-1:50
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
200ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the N-terminal region of human CDH6 (KLH).

Purity:

Purified by immunoaffinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human K Cadherin.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005). 2. Shimoyama,Y., Biochem. J. 349(PT 1), 159-167 (2000). 3. Shimoyama,Y., J. Biol. Chem. 274 (17), 11987-11994 (1999).