Technical Data
CDH1, CT (E-Cadherin, Epithelial Cadherin, Uvomorulin, Cadherin-1, CAM 120/80, CD324, UVO) (FITC)
CDH1 is a classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.

Suitable for use in FLISA and Western Blot. Other applications not tested.

Recommended Dilution:
FLISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Note: Applications are based on unconjugated antibody.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As reported
Synthetic peptide selected from the C-terminal region of human CDH1 (KLH).
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Recognizes human CDH1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Mansouri,A., Differentiation 38(1), 67-71 (1988). 2. Knudsen,K.A. J. Cell Biol. 118(3), 671-679 (1992). 3. Hsu,Y.M., Cancer Res. 67(22), 11064-11073 (2007).