Technical Data
C0115-08Q
Calcitonin (CALCA, CALC1)
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Technical Data |
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C0115-08Q |
Calcitonin (CALCA, CALC1) |
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Description: Calcitonins (CTs) are a group of polypeptide hormones containing 32aa residues which share an amino terminal ring structure, with cysteines at 1 and 7 linked by a disulfide bridge, as well as a carboxy terminal prolinamide. It is usually synthesized in the parafollicular or C cells in the thyroid gland, and also in a wide variety of other tissues, including the lung and intestinal tract. It plays an active role in calcium homeostasis. A large number of diseases are associated with abnormally increased or decreased levels of calcitonin. Alternative RNA processing of human calcitonin: calcitonin gene-related peptide (CGRP) gene generates two mRNAs encoding the precursors of calcitonin and CGRP. It is used in the treatment of bone loss disorders because it inhibits osteoclast function. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:100 Optimal dilutions to be determined by the researcher. Positive Control: Thyroid or Medullary carcinoma Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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