Technical Data
C1035-20
Calmodulin Antagonist W-12 (N-(4-aminobutyl)-2-naphthalenesulfonamide hydrochloride)
25mg
Biochemicals Storage: -20°CShipping: RT
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.

Melting Point:
As Reported

Solubility:
As Reported

Method for Determining Identity:
Proton NMR (D2O) Spectroscopic Analysis and Mass Spectrometric Analysis

TLC Conditions:
As Reported

Chloride Content:
As Reported

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: 
All products should be handled by qualified personnel only, trained in laboratory procedures.

CAS Number:
89108-46-3

Molecular Formula:
C14H19CIN2O2S

Molecular Weight:
314.8
Source: Synthetic
Purity: ~90%
Form: As Reported

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
US Biological application reference: McFadden MJ, et al. Evaluation of the Calmodulin-SOX9 Interaction by “Magnetic Fishing” Coupled to Mass Spectrometry. Chembiochem. 2014 Sep 18. doi: 10.1002/cbic.201402414. [Epub ahead of print].
General references:
T. Tanaka and H. Hidaka; J. Biol. Chem. 255, 11078 (1980) [Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.