Technical Data
C1384-25
Cardiotin
Description:
Cardiotin is a high molecular weight protein complex (300kD) located in the longitudinal SR of cardiomyocytes. The cardiotin structure exists of subunits of 60kD and 100kD. Both subunits contain the same amino-terminal 14 amino acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. During cardiac contractile dysfunction, a decreased SR activity is detected. The cardiotin distribution is affected in pathological cardiomyocytes i.e. chronic ischemic myocardium.
TypeIsotypeCloneGrade
MabIgM2Q2275Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
300 kD cardiotin protein
Purity:
Purified immunoglobulin.
Form
Liquid in buffer with 0.1% sodium azide.
Specificity:
Reacts with cardiotin, a sacroplasmic/endoplasmic reticulum related protein. Reacts with the 300kD cardiotin protein complex and its 100kD and 60kD subunits by Western blot. Reacts with cardiomyocytes and epithelial cells. Species Reactivity: Human and porcine.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Schaart, G., et al., Biochemical characterization of cardiotin, a sarcoplasmic reticulum associated protein. FEBS Letters (1997) 403:168172.