Technical Data
C2069-39A
Catenin, p120, CT
Description:
Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:50
Western Blot: 1:1,000-5,000
Immunohistochemistry: 1:100-250
Immunocytochemistry: 1:250
Immunoprecipitation: 1:80

Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
TypeIsotypeCloneGrade
MabIgG6k67Supernatant
SizeStorageShippingSourceHost
100ul -20°CBlue IceHumanRabbit
Concentration:
Immunogen:
A synthetic peptide corresponding to residues near N-terminus (before aa101) of human p120 Catenin (isoform 1ABC, 968AA)
Purity:
Supernatant
Form
Supplied as a liquid.
Specificity:
Recognizes human p120 Catenin (isoform 1ABC, 968AA)
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Keirsebilck, A., et al. Genomics 50: 129–46 (1998). 2. Aho, S., et al. . J Cell Sci. 115: 1391–402 (2002). 3. van Hengel, J., et al. Proc Natl Acad Sci U S A. 96: 7980–5 (1999).