Technical Data
C2069-40N
CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)
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Technical Data |
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C2069-40N |
CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13) |
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Description: The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. a-Catenin is a 102kD protein that is associated with the cadherin indirectly through its interaction with b-catenin and g-catenin. b-Catenin and its homolog plakoglobin associate directly with the cadherin. Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either b-catenin or plakoglobin, which in turn assoctiates directly with a-catenin. a-Catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton (5,6). a-Catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2.5-5ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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