Technical Data
C2069-55D
Catenin, gamma (Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin-3, DP3, Desmoplakin III, Desmoplakin-III, DPIII, Gamma Catenin, Junction Plakoglobin, JUP)
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Technical Data |
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C2069-55D |
Catenin, gamma (Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin-3, DP3, Desmoplakin III, Desmoplakin-III, DPIII, Gamma Catenin, Junction Plakoglobin, JUP) |
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Description: Junction Plakoglobin (JUP), also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Application: Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry, and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Immunohistochemistry (frozen): 4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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