Technical Data
Cathepsin B (Cathepsin-B, CPSB, CTSB, Cathepsin B1, Amyloid Precursor Protein Secretase, APP Secretase, APPS, Preprocathepsin B, Procathepsin B)
Cathepsin B is thought to play an increasingly important role in apoptosis and its release from the lysosome under cell stress leads to Bid cleavage, cytochrome C release and nuclear fragmentation. Cathepsin B is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete processing of APP is thought to be a causative factor in Alzheimer disease.

Overexpression of cathepsin B has been associated with oesophageal adenocarcinoma and other tumors, and has in particular been implicated in tumor invasion and metastasis.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:2,000-1:20,000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
1ml4C/-20C (No Glycerol)Blue IceHumanSheep
Native, from placenta
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Recognizes human CATHEPSIN B.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.