Technical Data
C2097-93C
CAV1, NT (Caveolin-1, CAV)
Description:
The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. This protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The CAV1 gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanRabbit
Concentration:
~0.25mg/ml
Immunogen:
Synthetic peptide selected from the N-terminal region of human CAV1 (KLH).
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human CAV1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Smith,J.L.,J. Virol. 82(19), 9505-9512 (2008). 2.Zhong,Y., J. Neurosci. 28(31), 7788-7796 (2008). 3.Di Vizio,D., Cell Cycle 7(14), 2257-2267 (2008). 4.Lee,H., J. Biol. Chem. 276(37), 35150-35158 (2001). 5.Schlegel,A., J. Biol. Chem. 276(6), 4398-4408 (2001).