Technical Data
C2097-98A
Caveolin 3 (CAV 3, CAV3, Caveolin3, LGMD1C, M caveolin, MGC126100, MGC126101, MGC126129, VIP 21, VIP21)
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Technical Data |
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C2097-98A |
Caveolin 3 (CAV 3, CAV3, Caveolin3, LGMD1C, M caveolin, MGC126100, MGC126101, MGC126129, VIP 21, VIP21) |
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Description: This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin-embedded sections): 1:500 Western Blot: 1ug/ml. Detects caveolin 3 from rat heart homogenate at ~21kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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