Technical Data
C2098-70J
CBX3, ID (Chromobox Protein Homolog 3, HECH, Heterochromatin Protein 1 Homolog gamma, HP1 gamma, Modifier 2 Protein)
Description:
CBX3 seems to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. It may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). In addition, it is involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:32,000
Western Blot: 0.3-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to Internal Region of CBX3/HP1 Gamma: EAFLNSQKAGKEKD (KLH).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in TBS, 0.5% BSA, 0.02% sodium azide.
Specificity:
Recognizes human CBX3. Species sequence homology: Canine, mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.