Technical Data
C2099-65L
CCR1 (C-C Chemokine Receptor Type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 Receptor, Macrophage Inflammatory Protein 1-alpha Receptor, MIP-1alpha-R, RANTES-R, CD191, CMKBR1, CMKR1, SCYAR1)
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Technical Data |
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C2099-65L |
CCR1 (C-C Chemokine Receptor Type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 Receptor, Macrophage Inflammatory Protein 1-alpha Receptor, MIP-1alpha-R, RANTES-R, CD191, CMKBR1, CMKR1, SCYAR1) |
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Description: Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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