Technical Data
CCR1 (C-C Chemokine Receptor Type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 Receptor, Macrophage Inflammatory Protein 1-alpha Receptor, MIP-1alpha-R, RANTES-R, CD191, CMKBR1, CMKR1, SCYAR1)
Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to aa341 from human CCR1.
Purified by affinity chromatography.
Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Recognizes human CCR1 at ~42kD. Species Crossreactivity: mouse and monkey.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.