Technical Data
CCR3 (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)
Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ml
Immunohistochemistry: 10ug/ml
Optimal dilution determined by the researcher.

Positive control:
Human spleen tissue

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20°CBlue IceHumanRabbit
Synthetic peptide corresponding to 14aa near the carboxy terminus of human CCR3 (NP_847899).
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes human CCR3. Species crossreactivity: mouse, rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Feng, Y., et al., (1996), “HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor”, Science, 272: 872-877 2.Deng, H., et al., (1996), “Identification of a major co-receptor for primary isolates of HIV-1”, Nature, 381: 661-666 3.Choe, H., et al., (1996), “The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates”, Cell, 85: 1135-1148 4.He, J., et al., (1997), “CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia”, Nature, 385: 645-649 5.Zhang, L. et al., (1998), “In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3 and CCR5”, J. Virol., 72: 5035-50456.Combadiere, C., et al., (1995), “Cloning and functional expression of a human eosinophil CC chemokine receptor”, J. Biol. Chem., 270: 16491-16494