Technical Data
C2099-73R
CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9)
Description:
CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the C-terminal region of human CCBP2 (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human CCBP2. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Kunkel, E.J., et al., J. Clin. Invest. 111(7):1001-1010 (2003). 2.Fra, A.M., et al., J. Immunol. 170(5):2279-2282 (2003). 3.Soler, D., et al., Blood 101(5):1677-1682 (2003). 4.Nibbs, R.J., et al., Am. J. Pathol. 158(3):867-877 (2001). 5.Bonini, J.A., et al., DNA Cell Biol. 16(10):1249-1256 (1997).