Technical Data
C2099-74G
CCR10 (CC Chemokine receptor 10, CC-CCR-10, G protein-coupled receptor 2, GRP2)
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Technical Data |
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C2099-74G |
CCR10 (CC Chemokine receptor 10, CC-CCR-10, G protein-coupled receptor 2, GRP2) |
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Description: CC chemokine receptor 10/G protein-coupled receptor 2 (CCR-10/GRP2) is the receptor for the skin-associated CC chemokine CCL27 (CTACK/ALP/ILC). CCR-10 and MEC (mucosal epithelial ligand for CCR-10) play a role in unifying the localization of IgA plasma cells to the physically dispersed organs of the secretory IgA immune system. CCL27-CCR-10 interactions regulate T cell-mediated skin inflammation. CCL27-CCR-10 expression is increased in allergic contact dermatitis, indicating that it could be responsible for local skin memory. CCL27-CCR-10 expression may be involved in the selective recruitment to the skin of cytotoxic lymphocytes in epidermal necrolysis, Stevens-Johnson syndrome, and less severe drug-induced cutaneous diseases. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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