Technical Data
C2099-76
CCR1 (Chemokine Receptor 1, CC-CKR-1)
Description:
Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

Application(s):
ELISA 1:50,000
Western Blotting: 1:1,000. Western Blot on membranes from human peripheral blood leukocytes or human T-cell line Jurkatt.
Immunohistochemistry: 1:300

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ul-20CBlue IceHumanRabbit
Concentration:
Not determined
Immunogen:
Synthetic Peptide TEDYDTTTEFDYGDATPC and corresponds to amino acid residues 7-24 of human C-C Chemokine Receptor 1.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide before the addition of 40% glycerol.
Specificity:
Peptide sequence shares less than 50% amino acid identity to other Chemokine receptors in this region. Since the peptide sequence shares less than 50% amino acid identity to other chemokine receptors in this region, this antibody only recognizes human receptor. Crossreacts with human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Neote K, DiGregorio D, Mark J. Y.,Horuk. R.and Schall T.J. 1993. "Molecular Cloning, Functional Expression, and Signaling Characteristics of a C-C Chemokine Receptor." Cell. 72, 415-425.
2. Su S.B., Mukaida N., Nomura. H and Matsushima. K. 1996. "Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1expression on various types of leukocytes."
3. J. Leukoc., Biol 60(5), 658-666.