Technical Data
C2099-90C
CCR1 (Chemokine Receptor 1, CC-CKR-1, CC-CCR-11)
Description:
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Hybridoma:
Sp2/0-Ag14 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG1,k10g166Affinity Purified
SizeStorageShippingSourceHost
500ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
15 amino-acid peptide corresponding to the amino acid sequence 305-319 of human CCR1.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a lyophilized powder in 0.01M PBS, pH 7.0. Reconstitute with sterile ddH2O to 1mg/ml.
Specificity:
Recognizes the above peptide conjugated KLH in EIA. Species crossreactivity: Does not cross react with KLH, BSA and HSA.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.