Technical Data
C2099-91E
CCR2 (C-C Chemokine Receptor Type 2, Chemokine (C-C Motif) Receptor 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, CD192, Monocyte Chemoattractant Protein 1 Receptor, MCP-1-R)
Description:
CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage traffickingis and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis (Ruth et al., 2001). ESTs have been isolated from liver/spleen and prostate libraries.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 2-5ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human spleen, lymphocytes

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20°CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to the 2nd extracellular domain of human CCR2.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
Specificity:
Recognizes human CCR2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.