Technical Data
C2099-92V
CCR3 (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)
Description:
CCR3, a Chemokine Receptor, was cloned from human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils (Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human tonsil, lymphocytes

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20°CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to the 3rd extracellular domain of human CCR3 (KLH).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, 0.1% sodium azide.
Specificity:
Recognizes human CCR3.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. Pacheco-Rodriguez G, F Kumiyuki, W Steagall, Y Zhang, Y Ikeda, J Lin, E Billings, J moss. J Immunol 182: 1270-1277 (2009).