Technical Data
C2099-99L
CCR5 (Chemokine (C-C motif) Receptor 5, C-C Chemokine Receptor Type 5, CCCKR5, CC-CKR-5, C-C CKR-5, CCR-5, AM4-7, CD195, CHEMR13, CKR5, CMKBR5, FLJ78003, HIV-1 Fusion Coreceptor, IDDM22)
Description:
CCR5(CC chemokine receptor 5; also CD195 and MIP­1a receptor)is a 41­44kD member of the G­protein coupled receptor #1 family of proteins. It is expressed on Treg cells, NK cells, neurons,macrophages and Th1 cells. CCR5 mediates cell adhesion and migration induced by several chemokines including CCL3/MIP­1a, CCL4/MIP­1b, CCL5/RANTES, and CCL8/MCP­2. It also functions as a coreceptor for macrophage­tropic HIV1 infection. CCR5 contains O­
glycosylated and sulfated extracellular N­terminus (aa1­32), and a phosphorylated and palmitoylated intracellular C­terminus (aa304354). CR5 will form homodimers,heterodimers with CCR2,and heterooligomers with CCR2 and CXCR4. Within aa1­32, mouse CCR5 shares 72% and 91% aa sequence identity with human and rat CCR5, respectively.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 2mg/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG11D98Affinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceMouseRat
Concentration:
Not determined
Immunogen:
Recombinant corresponding to mouse CCR5 expressed in E. coli (P51682).
Purity:
Purified by Protein A/G affinity chromatography.
Form
Supplied as a lyophilized powder in PBS with trelahose. Reconstitute with sterile PBS.
Specificity:
Recognizes mouse CCR5.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.