Technical Data
C2099-99L
CCR5 (Chemokine (C-C motif) Receptor 5, C-C Chemokine Receptor Type 5, CCCKR5, CC-CKR-5, C-C CKR-5, CCR-5, AM4-7, CD195, CHEMR13, CKR5, CMKBR5, FLJ78003, HIV-1 Fusion Coreceptor, IDDM22)
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Technical Data |
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C2099-99L |
CCR5 (Chemokine (C-C motif) Receptor 5, C-C Chemokine Receptor Type 5, CCCKR5, CC-CKR-5, C-C CKR-5, CCR-5, AM4-7, CD195, CHEMR13, CKR5, CMKBR5, FLJ78003, HIV-1 Fusion Coreceptor, IDDM22) |
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Description: CCR5(CC chemokine receptor 5; also CD195 and MIP1a receptor)is a 4144kD member of the Gprotein coupled receptor #1 family of proteins. It is expressed on Treg cells, NK cells, neurons,macrophages and Th1 cells. CCR5 mediates cell adhesion and migration induced by several chemokines including CCL3/MIP1a, CCL4/MIP1b, CCL5/RANTES, and CCL8/MCP2. It also functions as a coreceptor for macrophagetropic HIV1 infection. CCR5 contains O glycosylated and sulfated extracellular Nterminus (aa132), and a phosphorylated and palmitoylated intracellular Cterminus (aa304354). CR5 will form homodimers,heterodimers with CCR2,and heterooligomers with CCR2 and CXCR4. Within aa132, mouse CCR5 shares 72% and 91% aa sequence identity with human and rat CCR5, respectively. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2mg/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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