Technical Data
C2100-15B
CCR10 (C-C Chemokine Receptor Type 10, Chemokine (C-C Motif) Receptor 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein Coupled Receptor 2, GPR2)
Description:
GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation. GRP2/CCR10 has been reported to be ubiquitously expressed. Transcripts for this receptor have been identified in peripheral tissues including adult small intestine and fetal liver, testis, placenta, and skin. In the skin, this receptor is constitutively expressed in melanocytes, fibroblasts, and microvascular endothelial cells. It is also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in keratinocytes (Homey et al., 2000), dendritic cells, or in various brain regions (Marchese et al., 1994). ESTs have been isolated from brain, eye, and kidney libraries.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 11-44ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human Thymus

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to the 2nd extracellular domain of human G Protein-Coupled Receptor CCR10.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
Specificity:
Recognizes human CCR10.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.