Technical Data
C2262-02H1
CD11a (Integrin Alpha L, ITGAL, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain, LFA1A, Ly15, Ly21, Lymphocyte Function Associated Antigen Type 1 alpha, p180)
Description:
CD11a is a member of the integrin family of cell adhesion molecules. It is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta 2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on thymocytes, T and B lymphocytes, granulocytes, monocytes, and macrophages.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG18J576Affinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
Tissue / cell preparation (Human). Peripheral blood lymphocytes.
Purity:
Purified by immunoaffinity chromatography.
Form
In PBS with 15mM Sodium Azide. pH 7.4
Specificity:
The antibody recognizes an unique epitope on CD11a antigen (LFA-1 alpha chain) implicated in activation of LFA-1 complex. Species Crossreactivity: Crossreacts with Human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Landis RC et al. Involvement of the I domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3. J Cell Biol 126:529-37 (1994).
2. Landis RC et al. A novel LFA-1 activation epitope maps to the I domain. J Cell Biol 120:1519-27 (1993).
3. Knapp W et al. (eds.) Leucocyte typing IV. Oxford University Press (1989).