CD11a is a member of the integrin family of cell adhesion molecules. It is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta 2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on thymocytes, T and B lymphocytes, granulocytes, monocytes, and macrophages.
Suitable for use in Flow Cytometry. Other applications not tested.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
|2ml ||-20°C||Blue Ice||Human||Mouse|
|Tissue / cell preparation (Human)-Leucocytes from a patient suffering from a LGL-type leukaemia.|
|Purified by Protein G affinity chromatography.|
|Sodium Azide. PBS, BSA. Labeled with FITC.|
|The antibody reacts with alpha-subunit (CD11a) of human LFA-1 (AlphaL integrin chain). Species Crossreactivity: Reacts with Human. |
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|
Larson RS et al. Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J Cell Biol 108:703-12 (1989). PubMed: 2537322|
Corbi AL et al. Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. J Exp Med 167:1597-607 (1988). PubMed: 3284962
Dustin ML et al. Supergene families meet in the immune system. Immunol Today 9:213-5 (1988). PubMed: 3076418
Kishimoto TK et al. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell 50:193-202 (1987). PubMed: 3594570
Search PubMed (MEDLINE) for references to CD11a