Technical Data
C2390-05
CD38 (Acute Lymphoblastic Leukemia Cells Antigen, ADP Ribosyl Cyclase, CADPr Hydrolase 1, Cyclic ADP Ribose Hydrolase, Ecto Nicotinamide Adenine Dinucleotide Glycohydrolase, I19 (Mouse), Lymphocyte Differentiation Antigen)
Description:
CD38 is a single chain type II integral transmembrane protein. It is highly expressed on thymocytes. It is also present on activated T cells and terminally differentiated B cells (plasma cells). Other reactive cells include NK cells, monocytes, macrophages, and dendritic cells. CD38 may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is not found on most mature resting peripheral lymphocytes. CD38 functions as a multicatalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells.

Applications:
Suitable for use in Immunohistochemistry. Not suitable for use in Western Blot. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry (Formalin/paraffin): 1:50-1:100 for 60 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes, followed by cooling at RT for 20 minutes. Requires use of a high-sensitivity detection system.
Optimal dilutions to be determined by the researcher.

Positive Control: Tonsil

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG10.N.110Supernatant
SizeStorageShippingSourceHost
500ul4°C (-20°C Glycerol)Blue IceHumanMouse
Concentration:
Not Determined
Immunogen:
Recombinant protein encoding the extracellular domain of human CD38. Epitope: Extracellular. Cellular Location: Cell membrane.
Purity:
Tissue culture supernatant
Form
Supplied as a liquid, 0.09% sodium azide.
Specificity:
Recognizes human CD38.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
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