Technical Data
C2414-02B
CD61 (Glycoprotein IIIa, Integrin beta3)
Description:
CD61 is the integrin beta3 subunit, a 105kD transmembrane glycoprotein expressed on platelets, megakaryocytes, and endothelial cells. Integrin beta3 associates with gpIIb (CD41) to form the CD41/CD61 complex that mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the alphaVbeta3 vitronectin receptor (1-5).

Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1ug/10e6 cells
Immunohistochemistry: Frozen and paraffin sections.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG15K291Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanMouse
Concentration:
~0.1mg/ml
Immunogen:
Human CD61
Purity:
Purified
Form
Supplied as a liquid in borate buffered saline, pH 8.0.
Specificity:
Recognizes human CD61.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford.
2. Kieffer, N., and D.R. Phillips. 1990. Annu, Rev. Cell. Biol. 6:34.
3. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD61 Section, Academic Press, New York, p. 293.
4. Davies, J., J. Warwick, N. Totty, R. Philp, M. Helfrich, and M. Horton. 1989. J. Cell Biol. 109:1817.
5. Bray, P.F. 1994. Thromb. Haemost. 72:492.