Technical Data
C2446-71E
CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (PE)
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Technical Data |
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C2446-71E |
CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (PE) |
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Description: CD106, also known as INCAM-1, is a 100-110kD vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. This antibody inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium (1-4). Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul/10e6 cells Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light. |
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