		Technical Data
C2581-01D	CDR2 (Cerebellar Degeneration-related Protein 2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplastic Antigen, PCD17)

Description:
CDR2 (Cerebellar degeneration related protein 2) is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons. Patients with PCD carry a characteristic antibody called anti-Yo. Anti-Yo sera reacts with at least 2 antigens, a major species CDR2, and a minor species CDR1.

Applications:
Suitable for use in ELISA, Immunofluorescence, and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG2a,k	4F5	Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Mouse

Concentration:

As reported

Immunogen:

CDR2 (NP_001793, 296-405aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.

Purity:

Purified.

Form

Supplied as a liquid in PBS, pH 7.2.

Specificity:

Recognizes human CDR2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.The Onconeural Antigen cdr2 Is a Novel APC/C Target that Acts in Mitosis to Regulate C-Myc Target Genes in Mammalian Tumor Cells. O'Donovan KJ, Diedler J, Couture GC, Fak JJ, Darnell RB.PLoS One. 2010 Apr 7;5(4):e10045.