Technical Data
C2589-51E
Cdx-2, Homeobox Protein (Caudal-type Homeobox Protein 2)
Description:
CDX2 (caudal-type homeobox protein 2), is a nuclear protein and member of the caudal homeobox family, which acts as a regulator for intestinal epithelium gene transcription, and possibly for the differentiation and proliferation of intestinal epithelial cells.
Studies have revealed the expression of CDX2 in intestinal-type gastric cancer, colorectal carcinomas and intestinal metaplasia of the stomach, and have implicated CDX2 as an early marker of Barrett's oesophagus, the premalignant lesion of oesophageal adenocarcinoma (EAC).

Applications:
Suitable for usein ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:4000
Western Blot: 1-3ug/ml. detects a band of approximately 38kD in human kidney and liver cell lysates.
Optimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanGoat
Concentration:
~0.5mg/ml
Immunogen:
Peptide sequence EQLSPGGQRRNLCE corresponding to the internal region of CDX2 (NP_001256.1).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide and 0.5% BSA.
Specificity:
Recognizes human CDX2. Species sequence homolgy: mouse, rat, canine. Not expected to recognize CDX1 or CDX4.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.