Technical Data
Cdx-2, Homeobox Protein (Caudal-type Homeobox Protein 2)
CDX2 (caudal-type homeobox protein 2), is a nuclear protein and member of the caudal homeobox family, which acts as a regulator for intestinal epithelium gene transcription, and possibly for the differentiation and proliferation of intestinal epithelial cells.
Studies have revealed the expression of CDX2 in intestinal-type gastric cancer, colorectal carcinomas and intestinal metaplasia of the stomach, and have implicated CDX2 as an early marker of Barrett's oesophagus, the premalignant lesion of oesophageal adenocarcinoma (EAC).

Suitable for usein ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:4000
Western Blot: 1-3ug/ml. detects a band of approximately 38kD in human kidney and liver cell lysates.
Optimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
100ug-20CBlue IceHumanGoat
Peptide sequence EQLSPGGQRRNLCE corresponding to the internal region of CDX2 (NP_001256.1).
Purified by affinity chromatography.
Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide and 0.5% BSA.
Recognizes human CDX2. Species sequence homolgy: mouse, rat, canine. Not expected to recognize CDX1 or CDX4.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.