Technical Data
Chaetocin (Chetocin)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is a specific inhibitor for the lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.

DMSO, DMF, methanol and ethanol. Poorly soluble in water

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Source: Chaetomium sp.
Purity: > 99% by HPLC
Form: White solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Isolation and configuration of Chaetocin. Hauser, D. et al. Helv. Chim. Acta 1970, 53, 1061. 2. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D. et al. Nature Chem. Biol. 2005, 1, 143. 3. Chaetocin, a promising new anti-myeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Isham C.R. et al. Blood 2007, 109, 2579.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.