Technical Data
C3430-45
Chaetocin (Chetocin)
1mg
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Technical Data |
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C3430-45 |
Chaetocin (Chetocin) |
1mg |
| Biochemicals | Storage: 4°C/-20°CShipping: Blue Ice |
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Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is a specific inhibitor for the lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress. DMSO, DMF, methanol and ethanol. Poorly soluble in water CAS Number: 28097-03-2 Molecular Formula: C30H28N6O6S4 Molecular Weight: 696.85 |
Source: Chaetomium sp. Purity: > 99% by HPLC Form: White solid Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Isolation and configuration of Chaetocin. Hauser, D. et al. Helv. Chim. Acta 1970, 53, 1061. 2. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D. et al. Nature Chem. Biol. 2005, 1, 143. 3. Chaetocin, a promising new anti-myeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Isham C.R. et al. Blood 2007, 109, 2579.
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