|Biochemicals||Storage: RTShipping: RT|
Chloramphenicol is a chlorine-containing antibiotic produced by Streptomyces venezuelae. It has a wide spectrum of activity against gram-positive and gram-negative cocci and bacilli (including anaerobes), Rickettsia, Mycoplasma, and Chlamydia. It inhibits prokaryotic protein synthesis by attaching to the 50S ribosomal subunit. This inhibits peptidyltransferase, thereby preventing the formation of peptide bonds. It also inhibits protein synthesis in mitochondria which accounts for its toxic effects that cause aplastic anemia. Chloramphenicol has other adverse effects such as bone marrow depression, and gray baby syndrome. It’s use is limited to serious infections such as those where resistance to other antibiotics occurs. It is still widely used in the treatment of typhoid fever, meningitis and eye infections.
Appearance: White to off-white crystalline powder
Solubility (MeOH): Colorless, clear, complete.
Chloramphenicol is slightly soluble in water. It is readily soluble in in alcohol, propylene glycol, acetone, ethyl acetate.
Specific Rotation: +18.5°+20.0°
Melting Point: 149-153°C
Stock Concentration: 10mg/ml
Working Concentration: 20ug/ml
Meets or exceeds USP Specifications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
US Biological application reference: Dennis, A.M. et al., (2010) Bioconjugate Chem. 21; 1160-1170.