Technical Data
C5038
Chlorzoxazone, substrate for Cytochrome P450 2E
5mg
Molecular Biology Storage: RTShipping: RT
Appearance:
White Powder with a faint Yellow cast

Solubility:
Clear, very faint Yellow solution, 50mg/ml in Methanol

IR Spectrum:
Consistant with Structure

Purity:
>99% by thin-layer chromatography

Storage and Stability:
Stable at RT

CAS Number:
95-25-0

Molecular Formula:
C7H4ClNO2 (5-Chloro-2-hydroxybenzoxazole)

Molecular Weight:
169.6
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1 Scott, R.J., Palmer, J., Lewis, I.A.S., et al. Determination of a «GW cocktail» of cytochrome P450 probe substrate and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry. Rapid Commun Mass Spectrom 13 2305-2319 (1999).
2 Frye, R.F., Adedoyin, A., Mauro, K., et al. Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: Choice of dose and phenotypic trait measure. J Clin Pharmacol 38 82-89 (1998).
3 Court, M.H., Von Moltke, L.L., Shader, R.I., et al. Biotransformation of chlorzoxazone by heptic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos 18 213-226 (1997).
4 Peter, R., Bocker, R., Beaune, P.H., et al. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450 2E1. Chem Res Toxicol 3 566-573 (1990).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.