Technical Data
C5069-96K
Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)
Description:
Chromogranin A (CgA) is a 49kD protein which is a member of the granin/secretogranin family of acidic glycoproteins. It is specifically expressed in all endocrine and neuroendocrine cells and plays multiple roles in the process of regulated secretion of peptide hormones and neurotransmitters. Owing to its over-expression in several tumors of neuroendocrine origin, CgA is of diagnostic value in classical endocrine, in hormone-negative and in neuroendocrine tumors.

Applications:
Suitable for use in ELISA and Flow Cytometry. Other applications not tested.

Recommended Dilution:
ELISA: 1:200-1:400
Flow Cytometry: 1.2ug/1x1056 cells
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

TypeIsotypeCloneGrade
MabIgG19E86Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
Immunogen:
Genetic immunisation with cDNA encoding CGA
Purity:
Purified by Protein G chromatography.
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
Recognizes human Chromogranin A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Hendy GN, Bevan S, Mattei MG, Mouland AJ (1995). Chromogranin A. Clin Invest
Med;18(1):47-65. 2. Deftos LJ (1991). Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev; 12(2):181-7.