Technical Data
C5069-97D
Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)
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Technical Data |
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C5069-97D |
Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI) |
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Description: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. Applications: Suitable for use in ELISA (peptide) and Western Blot. Other applications not tested. Recommended Dilution: ELISA (peptide): 1:4000 (detection limit). Western Blot: 0.1-0.3ug/ml. ~ 50kD band observed in human kidney lysates (calculated MW of 50.7kD according to NP_001266.1). Optimal dilutions to be determined by the researcher. Positive Control: Human Kidney lysate Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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