Technical Data
CUEDC2 (CUE Domain-containing Protein 2, C10orf66, HOYS6)
CUEDC2 is a 287aa protein belonging to the CUEDC2 family with a CUE domain. CUEDC2 is known to interact with PGR and ESR1 with the help of its CUE domain. The exact function of CUEDC2 is yet unknown, but reports suggest that it interacts with PR and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 participates in ubiquitination and subsequent proteasomal degradation of PGR and ESR1 and thus control their protein levels and plays an important role in breast cancer proliferation. Studies on CUEDC2 suggest that it acts as an adaptor protein that interacts with IKK and regulates IKK dephosphorylation by recruiting PP1.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
MCF7 and NIH 3T3 cell lysates

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to aa250-300 of human CUEDC2.
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Recognizes human CUEDC2. Species Crossreactivity: chimpanzee, bovine, canine, equine, porcine, mouse, rhesus monkey. Species sequence homology: opossum, rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Strausberg, RL. et al. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903 (2002). 2. Zhang, PJ. et al. EMBO. J. 26:1831-1842 (2007). 3. Hui-Yan Li, et al. Nature Immunology. 9:533-541 (2008).