Technical Data
C5071-30A
Chrysomycin B (Chrysomycin M, Virenomycin M, Albacarcin M)
500ug
Biochemicals Storage: +4CShipping: Blue Ice
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.

Purity: >98% by HPLC

Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.

Related to: Chrysomycin A, Gilvocarcin M, Gilvocarcin V, O-Deacetyl-ravidomycin

CAS Number:
83852-56-6

Molecular Formula:
C27H28O9

Molecular Weight:
496.51
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated
gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921.
2. Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000.
3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent
inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.