Technical Data
C5500-03A
CIS-1 (Cytokine-Inducible SH2-containing Protein-1, Suppressor of Cytokine Signalling, SOCS, Protein G18, CISH)
Description:
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:
Suitable for use in Western Blot and Immunofluorescence. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabPurified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
CISH (NP_659508.1, 1-258aa) full-length human protein.
Purity:
Purified.
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
Recognizes human CISH.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.