Technical Data
C5838-17A
Claudin 2 (Claudin-2, CLDN2, PSEC0059, SP82, UNQ705/PRO1356)
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Technical Data |
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C5838-17A |
Claudin 2 (Claudin-2, CLDN2, PSEC0059, SP82, UNQ705/PRO1356) |
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Description: Claudin-2, a 22kD integral membrane protein, is a member of Claudin family and was discovered along with Claudin-1. It is also a vital component of tight junction strands and consists of 2 extracellullar loops, 4 hydrophobic transmembrane domains and a cytoplasmic tail containing PDZ-binding motif. Studies on MDCK cells suggest that Claudin-2 determines the overall transepithelial membrane resistance properties and increases conductance by forming cation-selective channels in tight junction of epithelial cells. Claudin-2 is differentially expressed in the intestine and has been suggested to be involved in the regulation of intestinal cell monolayer barrier function through immune modulators such as interleukins. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:100-1:200 Optimal dilutions to be determined by the researcher. Positive Control: Ovarian carcinoma, tonsil Cellular Localization: Cytoplasmic and cell membrane Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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